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. 2017 Apr 10;13(6):4002–4012. doi: 10.3892/ol.2017.6016

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Copyright: © Hernandez-Unzueta et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Effect of the combined treatment of irinotecan and OOS^® on the tumor infiltration of macrophages in vivo. Expression level of F4/80 was analyzed in liver tissue by immunohistochemistry. (A) Images showing F4/80 expression (brown) and hematoxylin (purple) in liver tissue collected from untreated and treated mice. Image magnification was ×20. (B) F4/80 expression was quantified in livers collected from untreated and treated C26-bearing mice. Data are calculated as % of F4/80 expression per tumor foci area. At least 6 mice per group were used and differences were considered statistically significant at *P<0.05.