Table III.
Proteins significantly and differentially secreted in BOL and HGSOC cells.
| Quantification value | |||||
|---|---|---|---|---|---|
| Proteins | Accession no. | MW, kDa | P-value | BOL | HGSOC |
| Insulin-like growth factor-binding protein 2a | P18065 | 35 | <0.001 | 5.3±2 | 15.3±0.9 |
| Insulin-like growth factor-binding protein 7b | Q16270 | 29 | <0.001 | 28±2.9 | 15±1.3 |
| Macrophage colony-stimulating factor 1a | P09603 | 60 | <0.001 | 0 | 2.6±0.3 |
| Connective tissue growth factorb | P29279 | 38 | 0.006 | 4±2 | 0 |
| Neuroblastoma suppressor of tumorigenicity 1b | P41271 | 19 | 0.006 | 1.3±0.7 | 0 |
| Dickkopf-related protein 3b | Q9UBP4 | 38 | 0.010 | 11.7±2.2 | 3.8±1.3 |
| Keratin, type II cytoskeletal 1a | P04264 | 66 | 0.013 | 4.7±0.3 | 10.4±1.1 |
| Monocyte differentiation antigen CD14b | P08571 | 40 | 0.021 | 6.3±3.5 | 0.6±0.4 |
| SPARCb | P09486 | 35 | 0.021 | 53±8.2 | 32.6±3.4 |
| Tenascin-Xb | P22105 | 464 | 0.023 | 36.6±20.3 | 4.6±1.9 |
| Inter-α-trypsin inhibitor heavy chain H5b | Q86UX2 | 105 | 0.023 | 2.7±1.8 | 0 |
| Tenascinb | P24821 | 241 | 0.023 | 5.3±3.5 | 0 |
| Fibronectinb | P02751 | 263 | 0.024 | 162.7±65.5 | 59.1±6.9 |
| Gelsolinb | P06396 | 86 | 0.027 | 6.3±0.3 | 2.9±0.8 |
| 10 kDa heat shock protein, mitochondrialb | P61604 | 11 | 0.030 | 0 | 1.6±0.4 |
| Malate dehydrogenase, mitochondriala | P40926 | 36 | 0.031 | 2.7±1.5 | 7.9±1.1 |
| α-2-HS-glycoproteina | P02765 | 39 | 0.036 | 1.7±0.9 | 3.3±0.3 |
| Vimentinb | P08670 | 54 | 0.037 | 26.7±4.8 | 12.8±3 |
| Prostaglandin-H2 D-isomerasea | P41222 | 21 | 0.038 | 1±1 | 4±0.7 |
| Peroxiredoxin-2a | P32119 | 22 | 0.043 | 0 | 3.9±1 |
| Sulfhydryl oxidase 1a | O00391 | 83 | 0.048 | 6.7±1.9 | 15.8±2.3 |
a
Proteins with a significantly increased level of secretion by HGSOC cells vs. BOL cells.
b
Proteins with a significantly decreased level of secretion by HGSOC cells vs. BOL cells. BOL, benign ovarian lesion; HGSOC, high-grade serous ovarian carcinoma; CD14, cluster of differentiation; MW, molecular weight.