Table V.
The nine significantly secreted proteins identified in control/benign and ovarian cancer cells were evaluated for their potential clinical value by analyzing the association between their mRNA expression levels and patient mortality, using two alternate publically available datasets.
| Genes | TCGA-OVAD database P-value | GSE13876 database P-value |
|---|---|---|
| Gelsolin | 0.434 | 0.589 |
| Dickkopf-related protein 3 | 0.083 | 0.241 |
| Connective tissue growth factor | 0.008a | 0.962 |
| Insulin-like growth factor-binding protein 2 | 0.221 | 0.013a |
| Insulin-like growth factor-binding protein 7 | 0.871 | 0.568 |
| Macrophage colony-stimulating factor 1 | 0.356 | ND |
| Malate dehydrogenase, mitochondrial | 0.496 | 0.193 |
| Vimentin | 0.305 | 0.018a |
| 10 kDa heat shock protein | ND | ND |
| Sum of these genes | 0.18 | 0.048a |
a
P<0.05 ND, not determined