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Structures of LSD1/KDM1A and LSD2/KDM1B. (A) Domain architectures of human LSD1 and LSD2. (B) Tertiary structure of LSD1 in complex with CoREST and an H3-like peptide inhibitor (PDB ID: 2V1D). Domains are colored as in panel (A), CoREST is depicted in pink, and the H3-like peptide is depicted in orange. (C) Tertiary structure of LSD2 (PDB ID: 4HSU) in complex with an H3 peptide (residues 1–26) (orange) and the NPAC linker region (cyan).
