Table 1.
Somatic mutations in epigenetic regulator genes or histone genes in brain cancers.
| Gene mutated | Tumor | Reference |
|---|---|---|
| H3F3A (encoding H3.3 with K27M) | High-grade glioma | 29, 30, 41, 42, 46 |
| HIST1H3B (encoding H3.1 with K27M) | High-grade glioma | 30, 41, 46 |
| H3F3A (encoding H3.3 with G34R or G34V) | High-grade glioma | 29, 41, 42, 46 |
| NF1 | GBM | 46, 78 |
| SET2 (KMT3A) | High-grade glioma | 36 |
| GBM | 46 | |
| MLL2 (MLL4, KMT2C) | Medulloblastoma | 50, 95, 96, 97, 98, 99 |
| GBM | 46 | |
| MLL3 (KMT2D) | Medulloblastoma | 95 |
| GBM | 46 | |
| EZH2 (KMT6A) | GBM | 46 |
| LSD1 (KDM1A) | Medulloblastoma | 99 |
| JMJD1A (KDM3A) | Medulloblastoma | 99 |
| JMJD2C (KDM4C) | Medulloblastoma | 99 |
| JARID1A (KDM5A) | Medulloblastoma | 99 |
| JARID1B (KDM5B) | Medulloblastoma | 99 |
| JARID1C (KDM5C) | High-grade glioma | 36 |
| UTX (KDM6A) | Medulloblastoma | 50, 99 |
| GBM | 46 | |
| JMJD1C (KDM7A) | Medulloblastoma | 99 |
| HDAC2 | GBM | 46 |
| HDAC9 | Medulloblastoma | 99 |