. Author manuscript; available in PMC: 2017 Jun 1.

Published in final edited form as: Curr Pharm Des. 2014;20(17):2881–2898. doi: 10.2174/13816128113199990594

Table 2. Kinase Activating Mutations [5].

Protein domain	Cancer	Mutation	Reference
extracellular	RMS	C56S	[63]
IgI		R72L
Acidic box		T122A
IgII		A175T
IgII		R234H
transmembrane
cytoplasmic	RMS	N535D/K	[63]
		V550L/M
		A554V
		G576D
	Lung	P712T	[116], [188]
	Breast	V550L/M	[116]