Table 3.

The effect of oral administration and i.p. injection of ENPs on Hb derivatives (expressed as percent of total hemoglobin) in rats.

parameter	Oxy-Hb		MetHb		S-Hb		Co-Hb
group	Oral	IP	Oral	IP	Oral	IP	Oral	IP
Control	95.94 ± 0.87aA	96.24 ± 1.05aA	3.56 ± 0.74aA	3.22 ± 0.74aA	0.120 ± 0.01aA	0.118 ± 0.03aA	0.36 ± 0.18aA	0.432 ± 0.14aA
4 h	95.83 ± 1.75aA	95.17 ± 0.74aA	3.47 ± 0.80aA	3.43 ± 0.79aA	0.114 ± 0.03aA	0.115 ± 0.04aA	0.624 ± 0.20bA	0.688 ± 0.19bA
48 h	95.39 ± 1.13aA	95.65 ± 1.11aA	3.83 ± 0.67aA	3.64 ± 0.69aA	0.099 ± 0.02aA	0.120 ± 0.03aA	0.678 ± 0.19bA	0.639 ± 0.21bA
One week	95.72 ± 1.75aA	95.42 ± 2.78aA	3.88 ± 0.80aA	3.82 ± 0.83aA	0.117 ± 0.04aA	0.122 ± 0.04aA	0.682 ± 0.22bA	0.709 ± 0.23bA
Three weeks	95.49 ± 1.32aA	95.05 ± 1.27aA	3.99 ± 0.83aA	4.41 ± 0.79bA	0.156 ± 0.02aA	0.128 ± 0.01aA	0.400 ± 0.11aA	0.404 ± 0.12aA

All data are expressed as the mean ± standard error; means with different superscript letters are significantly different (p ≤ 0.05); lowercase letters (a, b) are for groups within the same column, while uppercase letter (A) to compare oral treatment with IP treatment within the same row.