Table 1.

Clozapine dose-dependently reduced EAE parameters.

	Vehicle	10 mg/kg	30 mg/kg	60 mg/kg
% incidence (n)	96% (50)	95% (20)	89% (35)	60% (40)
Max disease score (SEM)	3.7 (0.1)	3.0 (0.3)	3.0 (0.2)	2.1 (0.4)**
Disease score @d20 (SEM)	3.1 (0.1)	2.3 (0.4)	2.8 (0.3)	1.5 (0.5)**
Day of onset (SEM)	10.1 (1.7)	11.5 (1.1)	12.1 (1.1)	16.8 (0.9)**

^**p < 0.01 by one-way ANOVA with Dunnett’s multiple comparison test (max score & score @ d20) and Mantel–Cox log-rank test (day of onset) compared to vehicle control.