Table 3. Results of parametric statistical testing using model comparison between linear mixed models.
Simple effects of factors isoflurane level and direction or recording site were tested against the null model; interaction effects isoflurane level times direction and isoflurane level times recording site were tested against the additive models isoflurane level + direction and isoflurane level + recording site, respectively. *** as defined in Table 2.
| animal | measure | effect | BIC | deviance | df | p | |
|---|---|---|---|---|---|---|---|
| Ferret 1 | TESPO | null model | 345430.8 | 345401.7 | NA | NA | NA |
| isoflurane level | 345421.5 | 345373.1 | 28.58 | 2 | < < 0.000*** | ||
| direction | 342828.4 | 342789.7 | 2612.04 | 1 | < < 0.000*** | ||
| isoflurane l. + direction | 342819.3 | 342761.3 | NA | NA | NA | ||
| isoflurane l. × direction | 342139.9 | 342062.4 | 698.84 | 2 | < < 0.000*** | ||
| AIS | null model | 37581.2 | 37551.8 | NA | NA | NA | |
| isoflurane level | 37555.8 | 37506.8 | 46.00 | 2 | < < 0.000*** | ||
| recording site | 33296.2 | 33256.9 | 4294.82 | 1 | < < 0.000*** | ||
| isoflurane l. + recording site | 33270.9 | 33212.1 | NA | NA | NA | ||
| isoflurane l. × recording site | 30754.3 | 30675.8 | 2536.29 | 2 | < < 0.000*** | ||
| H | null model | 353650.8 | 353621.8 | NA | NA | NA | |
| isoflurane level | 353653.1 | 353604.7 | 17.03 | 2 | <0.000*** | ||
| recording site | 353446.8 | 353408.1 | 213.64 | 1 | < < 0.000*** | ||
| isoflurane l. + recording site | 353449.1 | 353391.1 | NA | NA | NA | ||
| isoflurane l. × recording site | 347204.7 | 347127.2 | 6263.85 | 2 | < < 0.000*** | ||
| Ferret 2 | TESPO | null model | 131164.7 | 131135.3 | NA | NA | NA |
| isoflurane level | 131152.3 | 131103.2 | 32.06 | 2 | < < 0.000*** | ||
| direction | 131168.9 | 131129.6 | 5.66 | 1 | 0.020 | ||
| isoflurane l. + direction | 131109.5 | 131097.5 | NA | NA | NA | ||
| isoflurane l. × direction | 130871.5 | 130793.0 | 304.56 | 2 | < < 0.000*** | ||
| AIS | null model | 109203.1 | 109173.7 | NA | NA | NA | |
| isoflurane level | 109183.1 | 109134.1 | 39.63 | 2 | < < 0.000*** | ||
| recording site | 105827.2 | 105788.0 | 3385.68 | 1 | < < 0.000*** | ||
| isoflurane l. + recording site | 105807.3 | 105748.4 | NA | NA | NA | ||
| isoflurane l. × recording site | 104173.5 | 104095.0 | 1653.46 | 2 | < < 0.000*** | ||
| H | null model | -14074.8 | -14104.2 | NA | NA | NA | |
| isoflurane level | -14088.6 | -14137.7 | 33.43 | 2 | <0.000*** | ||
| recording site | -18423.0 | -18462.3 | 4358.04 | 1 | < < 0.000*** | ||
| isoflurane l. + recording site | -18436.7 | -18495.6 | NA | NA | NA | ||
| isoflurane l. × recording site | -19867.2 | -19945.7 | 1450.09 | 2 | < < 0.000*** |