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. 2017 Jun 1;12(6):e0178193. doi: 10.1371/journal.pone.0178193

Fig 2. Enrichment of CD4 T cells expressing CCR5 and markers of activation in genital mucosa relative to blood.

Fig 2

(A) Representative flow plots show that CD4 T cells from CVL, FS and CB are highly enriched for antigen-experienced CD4 T cells as evidenced by expression of CD45RO. Histograms show comparison of expression of CCR5, CD38, CXCR4, CD69, α4β7 and CD27 on genital and whole blood (WB) CD4 T cells. Naive CD4 T cells are overlaid in grey. (B) Distribution of HIV co-receptors CCR5 (n = 16 visits for CVL, 24 visits for FS, CB1, CB2, and WB), CXCR4 (n = 19 visits for CVL, 21 visits for FS, 22 visits for CB1, CB2, and WB), and expression of the integrin α4β7 (n = 22 visits for CVL, 27 visits for FS, CB1, CB2, and WB) on mucosal and blood CD4 T cells. (C) Correlation of CCR5, CXCR4 and α4β7 expression on FS and CB. (D) Distribution of activation markers CD38 (n = 21 visits for CVL, 25 visits for FS, CB1, CB2, and WB), CD69 (n = 14 visits for CVL, 15 visits for FS, CB1, CB2, and WB) and CD27 (n = 19 visits for CVL, 23 visits for FS, CB1, CB2, and WB) on mucosal and blood CD4 T cells (****, p < 0.0001; **, p < 0.01; *, p < 0.05).