Figure 3.

Porphyromonas gingivalis lipopolysaccharide (Pg-LPS) upregulates Wnt5a expression and downregulates secreted frizzled-related protein 5 (sFRP5) expression in human gingival epithelial cells (HGECs). HGECs were stimulated for 12 h with the indicated concentrations of Pg-LPS and analyzed for messenger RNA (mRNA) expression of (A) Wnt5a and (B) sFRP5 by quantitative polymerase chain reaction. Results were normalized against glyceraldehyde 3-phosphate dehydrogenase (GAPDH) mRNA. Data are means ± SD (n = 5 sets of cultures). *P < 0.05 and **P < 0.01 between indicated groups.