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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: J Mol Cell Cardiol. 2016 Aug 18;99:151–161. doi: 10.1016/j.yjmcc.2016.08.011

Fig. 6.

Fig. 6

Simulations showing that GS-458967 can effectively reduce spatial APD dispersion caused by ATX-II. (A) Space-time plots of membrane potential (top) and pseudo ECGs (lower) computed from a 165-rabbit myocyte transmural cardiac preparation in the presence of ATX-II during a “short-long-short” pacing protocol. (B) 0.03 μM GS-458967 markedly diminishes QT interval prolongation and APD dispersion as indicated by reduced T-wave amplitude. (C) 0.1 μM GS-458967 further reduced QT interval prolongation and reversed the repolarization gradient as demonstrated by inversion of the T-wave.