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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: J Mol Cell Cardiol. 2016 Aug 18;99:151–161. doi: 10.1016/j.yjmcc.2016.08.011

Fig. 8.

Fig. 8

GS-458967 can prevent spiral wave reentry in the setting of acquired Long-QT Syndrome. A two-dimensional simulated heterogeneous anisotropic rabbit ventricular tissue was activated using a paired stimulus (S1-S2) protocol. (A) Shows the control or drug-free case, (B) with ATX-II, (C) with ATX-II and 0.3 μM GS-4589677, (D) 16 nM Dofetilide, or (E) 16 nM Dofetilide and 0.3 μM GS-458967. Tissues (5 cm × 5 cm) were stimulated (S1) along left edge (endocardium) and this followed by a premature stimulus (S2) applied in the vulnerable window (see Methods). Six snapshots obtained following application of GS-458967, dofetilide or both at selected time points. Corresponding pseudo-ECGs are in the right panels. Membrane voltage values are indicated by the color gradient.