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Simulated and experimental measured APD90: To simulate enhancement of late INa with ATX-II, rate constant, μ2, was reduced by 40%.
| BCL = 5000 ms Fig. 5 | Experimental APD90 (ms) (mean values) | Simulated APD90 (ms) (mean values from 1000 APs) | |
|---|---|---|---|
|
| |||
| Cell 1 | Cell 2 | ||
| Control | 258.8 (n = 11) | 522 (n = 6) | 240.91 |
| ATX-II | 625.2 (n = 10) | 2305.2 (n = 12) | 497.02 |
| Relative change to ATX-II | 58.6% | 77.3% | 51.53% |
