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. Author manuscript; available in PMC: 2018 May 17.
Published in final edited form as: ACS Chem Neurosci. 2017 Jan 13;8(5):1019–1025. doi: 10.1021/acschemneuro.6b00339

Figure 3.

Figure 3

Effect of in utero exposure to CIT on fetal brain neurogenesis at GD17. (A) Immunohistochemistry shows a significant decrease in the mean number of cells staining positive for PH3 in the caudal sections of the fetal cortical SVZ after chronic exposure of timed-pregnant mice to CIT in drinking water: SVZ = cortical subventricular zone (*p = 0.0382 versus untreated). (B) The medial part of the fetal hippocampal neuroepithelium (Hip NE) showed a significant decrease in mean number of PH3+ cells in maternal CIT-exposed embryos (**p = 0.0012 vs untreated). (C) Chronic maternal CIT exposure results in a significant decrease in the mean number of PH3+ cells in the lateral and medial fetal ganglionic eminence (GE) in comparison to untreated (**p = 0.0015 and p = 0.0086, respectively). All comparisons were made by two-way ANOVA with Bonferroni correction. Each column represents mean ± SEM. Results were obtained from 1 embryo per dam with n = 4 dams for control and n = 3 dams for treatment.