Table 6. Genes associated with adipocyte IR also associated with systemic insulin resistance or T2D.
| Adipocyte insulin sensitivitya | Systemic insulin sensitivityb | |
|---|---|---|
| Gene | OIR vs OIS | IR vs IS |
| CFH | 1.27 | 1.6 |
| INPP5A | 0.91 | 0.67 |
| KLF15 | 0.72 | 0.63 |
| LIN7C | 0.93 | 0.66 |
| PTP4A1 | 0.94 | 0.66 |
| SLC2A4 | 0.75 | 0.59 |
| SLC7A10 | 0.74 | 0.63 |
| TF | 0.68 | 0.46 |
| UBAP2L | 0.94 | 0.62 |
| VEGFA | 0.87 | 0.65 |
| OIR vs OIS | T2D vs controlc | |
| ACVR1C | 0.81 | -21.6 |
| HADH | 0.87 | -17.3 |
| KIAA1109 | 1.09 | -6.3 |
| LOC441666 | 1.25 | -17.5 |
| LYRM5 | 0.91 | -13.1 |
| NOX4 | 1.28 | 22.6 |
a. Selected genes differentially expressed in subcutaneous WAT between the OIR and OIS group in the present study (FDR≤5%) (from S1 Table)
b. Elbein et al reported that 172 genes in total were differentially expressed in subcutaneous WAT between insulin resistant and sensitive subjects in analysis of all European and African Americans [9]. Insulin sensitivity was calculated from the insulin-modified, intravenous glucose tolerance test, Individuals in either tail of the distribution of the standardized residual of the insulin sensitivity measurement were categorized as either insulin sensitive (IS) or resitant (IR).
c Nilsson et al reported that 197 genes in total were differentially expressed in subcutaneous WAT between twins discordant for T2D [52].