. Author manuscript; available in PMC: 2018 Apr 1.

Published in final edited form as: Int J Tuberc Lung Dis. 2017 Apr 1;21(4):412–419. doi: 10.5588/ijtld.16.0428

Table 3.

Test performance for the diagnosis of active TB

	TST n (%)^* (95% CI)	Standard ELISpot^† n (%)^* (95% CI)	Enhanced ELISpot^† n (%)^* (95% CI)
Sensitivity
Definite/probable TB^‡	9/45 (20) (10–35)	18/43 (42) (27–58)	20/43 (45) (31–62)
Definite TB^§	6/16 (38) (15–65)	8/15 (53) (27–79)	10/15 (67) (38–88)
Specificity
No TB^¶	124/127 (98) (93–100)	105/119 (88) (81–94)	98/119 (82) (74–89)
Predictive values^#
PPV	9/12 (75) (43–95)	18/32 (56) (38–74)	20/41 (49) (33–65)
NPV	124/160 (78) (70–84)	105/130 (81) (73–87)	98/121 (81) (73–88)

All percentages rounded to the nearest whole number.

^†

ELISpot was invalid in 7% (3/46) of children with TB and 6% (8/127) of those with no TB.

^‡

Proportion of children testing positive for a given test among those with culture-confirmed or clinically diagnosed TB.

^§

Proportion of children testing positive for a given test among those with culture-confirmed TB only.

^¶

Proportion of children testing negative for a given test among those in whom TB was excluded.

Predictive values for definite/probable TB at baseline evaluation.

TB = tuberculosis; TST = tuberculin skin test; CI = confidence interval; ELISpot = enzyme linked immunospot based assay; PPV = positive predictive value; NPV = negative predictive value.