. Author manuscript; available in PMC: 2018 Apr 1.

Published in final edited form as: Int J Tuberc Lung Dis. 2017 Apr 1;21(4):412–419. doi: 10.5588/ijtld.16.0428

Table 4.

Effect of malnourishment, BCG vaccination and very young age on test performance for the diagnosis of active tuberculosis^*

	TST n (%)^† (95% CI)	Standard ELISpot n (%)^† (95% CI)	Enhanced ELISpot n (%)^† (95%CI)
Malnourished
Sensitivity	1/12 (8) (0–39)	4/11 (36) (11–70)	5/11 (46) (17–77)
Specificity	40/40 (100) (91–100)	31/38 (82) (66–92)	31/38 (82) (66–92)
BCG-vaccinated
Sensitivity	7/33 (21) (9–39)	10/30 (33) (17–53)	11/30 (37) (20–56)
Specificity	114/117 (97) (93–100)	97/109 (89) (82–94)	91/109 (84) (75–90)
Age <1 year
Sensitivity	2/12 (17) (2–48)	6/12 (50) (21–79)	6/12 (50) (21–79)
Specificity	15/15 (100) (78–100)	14/15 (93) (68–100)	13/15 (87) (60–98)

Diagnostic performance in HIV-coinfected children could not be calculated due to the very small sample size.

^†

All percentages rounded to the nearest whole number.

BCG = bacille Calmette-Guérin; TST = tuberculin skin test; CI = confidence interval; ELISpot = enzyme linked immunospot based assay; HIV = human immunodeficiency virus.