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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: J Med Chem. 2017 Jan 31;60(3):1210–1218. doi: 10.1021/acs.jmedchem.6b01792

Figure 4.

Figure 4

Compound pharmacology. (A) Cytotoxicity was measured by Alamar Blue assay in FRT cells incubated for 8 h with 10 μM 6k or 12, with 33% DMSO as positive control (mean ± SEM, n = 8). (B) In vitro metabolic stability. Compounds at 5 μM were incubated for indicated times with 1 mg/mL hepatic microsomes in the presence of NADPH and parent compound assayed by LC/MS (mean ± SEM, n = 3). LC/MS profile of 12 is shown on the right with elution time on the x-axis for incubation times of 0, 15, and 60 min.