Table 1.
Compd | Matrix | %NO Release | |||
---|---|---|---|---|---|
1 hr | 2 hrs | 4 hrs | 8 hrs | ||
DD-1 | L-Cys | 3.8 ± 0.4 | 5.9 ± 0.3 | 8.8 ± 0.4 | 9.3 ± 0.3 |
Serum | 10.0± 0.1 | 9.7± 0.3 | 8.5± 1.0 | 10.4± 0.2 | |
DD-2 | L-Cys | 3.5 ± 0 | 4.2 ± 0.1 | 5.2 ± 0.4 | 5.3 ± 0.3 |
Serum | 2.3± 2.0 | 7.0± 1.8 | 5.8± 0 | 5.1± 0.04 | |
DD-3 | L-Cys | 1.8 ± 0.07 | 3.1 ± 0.2 | 4.7 ± 0.07 | 5.1 ± 0.1 |
Serum | 41.5± 0.2 | 45.7± 1.4 | 50.6± 1.9 | 52.5± 0.5 |
The experiments were performed in duplicate or triplicate. All compounds were solubilized in DMSO (2%). Control experiments without test compound also contain 2% DMSO