Table 2.
Adjusted Standard Lipids and Apolipoprotein According to Functional Thyroid Categories
| Variable | Euthyroidism | SCH | HT | P for Linear Trend |
|---|---|---|---|---|
| Total cholesterol, mg/dL | 213 (212, 215) | 212 (208, 215) | 218 (212, 224) | 0.621 |
| LDL cholesterol, mg/dL | 126 (124, 127) | 124 (121, 127) | 128 (123, 133) | 0.976 |
| HDL cholesterol, mg/dL | 51.6 (51.1, 52.2) | 49.3 (48.2, 50.4)a | 49.4 (47.4, 51.4) | <0.001 |
| Triglycerides, mg/dL | 122 (120, 125) | 133 (128, 139)a | 141 (131, 153)a | <0.0001 |
| Triglycerides/HDL ratio | 2.4 (2.3, 2.4) | 2.7 (2.5, 2.9)a | 2.9 (2.6, 3.2)a | <0.0001 |
| ApoB, mg/dL | 105 (104, 106) | 106 (104, 109) | 112 (107, 116)a | 0.011 |
| ApoA1, mg/dL | 150 (149, 151) | 148 (146, 150) | 147 (143, 151) | 0.074 |
| ApoB/ApoA1 ratio | 0.73 (0.72, 0.74) | 0.74 (0.72, 0.76) | 0.80 (0.76, 0.84)a | 0.001 |
| Lp(a), mg/dL | 11.2 (10.6, 11.8) | 10.9 (9.7, 12.2) | 11.1 (9.1, 13.5) | 0.788 |
For linear regression across categories, adjustment covariates included age, race, household income, current smoking, systolic blood pressure, antihypertensive treatment, menopause status, and hormone replacement therapy. Least square means (95% CI) were determined.
a
P < 0.050 for pairwise comparison with euthyroid category (Bonferroni adjusted). Additional adjustment for BMI did not yield a change in P for trend across 0.05 thresholds.