Table 3.
Adjusted Analysis for Lipoprotein Particle Concentration and Size According to Functional Thyroid Categories
| Variable | Euthyroidism | SCH | HT | P for Linear Trend |
|---|---|---|---|---|
| VLDL particles | ||||
| Total, nmol/L | 61.8 (60.7, 62.8) | 62.7 (60.6, 64.9) | 65.2 (61.4, 69.1) | 0.084 |
| Large, nmol/L | 2.5 (2.4, 2.6) | 2.7 (2.5, 3.0) | 3.1 (2.7, 3.6)a | 0.002 |
| Medium, nmol/L | 16.9 (16.4, 17.3) | 17.8 (16.8, 18.7) | 19 (17.4, 20.7)a | 0.005 |
| Small, nmol/L | 36.1 (35.2, 36.9) | 36.0 (34.3, 37.8) | 35.6 (32.6, 38.7) | 0.804 |
| Average size, nm | 51.5 (51.2, 51.8) | 52.3 (51.7, 53) | 52.9 (51.8, 54.1)a | 0.001 |
| IDL partcles | ||||
| Total, nmol/L | 179 (175, 183) | 176 (167, 184) | 188 (174, 203) | 0.674 |
| LDL particles | ||||
| Total, nmol/L | 1283 (1267, 1299) | 1319 (1285, 1353) | 1358 (1298, 1418) | 0.004 |
| Large, nmol/L | 575 (564, 586) | 552 (529, 576) | 562 (520, 604) | 0.157 |
| Small pattern B 2225 (67.0%) | 668 (653, 684) | 734 (699, 770)a | 829 (759, 906)a | <0.001 |
| Small pattern A 1096 (33.0%) | 64.8 (63.0, 66.6) | 63.8 (60.0, 67.8) | 62.5 (56.5, 69.1) | 0.456 |
| Average size, nm | 21.1 (21.0, 21.1) | 21 (20.9, 21.1) | 21 (20.9, 21.1) | 0.024b |
| HDL particles | ||||
| Total, nmol/L | 37.4 (37.2, 37.7) | 37.3 (36.8, 37.8) | 37.1 (36.1, 38.0) | 0.431 |
| Large, μmol/L | 6.3 (6.2, 6.4) | 6.1 (5.8, 6.3) | 6.4 (5.9, 6.9) | 0.433 |
| Medium, μmol/L | 12.5 (12.3, 12.7) | 12.6 (12.1, 13) | 12.8 (12, 13.6) | 0.602 |
| Small, μmol/L | 18.7 (18.5, 18.9) | 19.1 (18.6, 19.5) | 18.1 (17.4, 18.9) | 0.904 |
| Average size, nm | 9.2 (9.2, 9.2) | 9.2 (9.1, 9.2) | 9.3 (9.2, 9.3) | 0.987 |
| Lipoprotein insulin resistance index scoreb | 49.2 (48.3, 50.2) | 52.1 (50.1, 54)a | 52.1 (48.6, 55.6) | 0.008b |
For linear regression across categories, adjustment covariates included age, race, household income, current smoking, systolic blood pressure, antihypertensive treatment, menopause status, and hormone replacement therapy. Least square means (95% CI) were determined. The small LDL pattern A group had 1096 individuals and the small LDL pattern B group had 2225 individuals, which corresponds to 33.0% and 67.0% of all those with available small LDL particles.
a
P < 0.050 for pairwise comparison with euthyroid category (Bonferroni adjusted).
b
Additional adjustment for BMI yield change in P for trend across 0.05 threshold.