Table 3. Differences of methylation levels between patients with and without AAC.

Gene	Position	AAC		P value
		With	Without
CDKN2A	1	4.20 (2.82–5.88)	4.33 (2.74–6.19)	0.571
	2	6.89 (5.30–8.90)	7.13 (5.51–8.55)	0.844
	3	8.09 (6.62–10.4)	8.02 (6.25–10.0)	0.379
	4	5.86 (4.25–7.81)	5.80 (4.38–7.87)	0.864
	5	4.80 (4.04–5.49)	5.08 (4.33–5.59)	0.132
	6	2.79 (2.34–3.36)	2.56 (2.09–3.07)	0.038
	7	2.33 (1.87–2.83)	2.27 (1.77–2.71)	0.174
	8	4.43 (3.78–5.08)	4.01 (3.56–4.67)	0.037
	9	4.30 (2.37–7.33)	5.26 (3.27–8.83)	0.130
	10	2.04 (0.96–3.23)	1.75 (1.00–2.56)	0.233
	11	3.57 (2.38–4.89)	3.70 (2.22–5.13)	0.885
	12	0.96 (0.57–1.34)	0.88 (0.56–1.25)	0.363
	13	1.20 (0.96–1.49)	1.34 (0.94–1.52)	0.441
	14	1.21 (1.03–1.46)	1.11 (0.88–1.41)	0.039
	15	2.05 (1.66–2.41)	1.93 (1.54–2.48)	0.630
	16	1.33 (1.02–1.66)	1.35 (1.08–1.62)	0.906
	17	3.23 (2.64–3.97)	3.01 (2.48–3.46)	0.005
	18	2.19 (1.71–2.61)	2.14 (1.74–2.53)	0.487
	19	2.49 (2.01–2.97)	2.48 (1.96–2.87)	0.827
	20	2.75 (2.18–3.27)	2.60 (2.10–3.07)	0.259
	21	15.5 (13.5–17.2)	15.6 (14.4–17.1)	0.313
	22	2.52 (2.08–3.15)	2.62 (2.07–3.20)	0.762
	23	4.27 (3.50–5.09)	4.32 (3.51–4.84)	0.853
	24	1.69 (1.26–2.46)	1.77 (1.31–2.48)	0.631
	Average	3.95 (3.58–4.27)	3.92 (3.67–4.23)	0.909
CDKN2B	1	5.43 (4.51–6.44)	4.97 (4.04–5.81)	0.005
	2	4.45 (3.48–5.34)	3.99 (3.06–5.06)	0.014
	3	3.89 (3.10–4.87)	3.86 (3.10–4.64)	0.700
	4	4.20 (3.53–5.11)	3.89 (3.14–4.41)	0.007
	5	7.66 (6.65–8.80)	6.65 (5.80–7.68)	< 0.001
	6	6.95 (5.99–8.12)	6.00 (5.04–6.80)	< 0.001
	7	8.12 (7.04–9.49)	7.10 (6.41–7.92)	< 0.001
	8	3.52 (3.03–4.11)	3.07 (2.76–3.49)	< 0.001
	9	3.94 (3.34–4.47)	3.41 (2.76–3.82)	< 0.001
	10	6.08 (5.21–7.03)	5.11 (4.20–5.92)	< 0.001
	11	7.53 (6.32–8.72)	6.56 (5.47–7.05)	< 0.001
	12	5.74 (5.02–6.70)	5.01 (4.37–5.60)	< 0.001
	Average	5.72 (5.03–6.34)	4.94 (4.48–5.47)	< 0.001