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. 2017 Jun 2;2(11):e93166. doi: 10.1172/jci.insight.93166

Figure 4. The β3-adrenergic pathway mediates thermoactivation of scBAT in mice.

Figure 4

(A) Effect of CL316243 (CL) treatment on relative expression of lipid, glucose uptake, and thermogenesis marker mRNA in iBAT and scBAT in 12-week-old mice. Data are presented as mean ± SEM. n = 4. ****P < 0.0001, ***P < 0.001, **P < 0.01, * P < 0.05; ns, nonsignificant (P > 0.05). Two-tailed t test for 2 groups and 1-way ANOVA for 4 groups. (B) Western blot image of UCP1 in iBAT and scBAT from 12-week-old mice treated with or without CL316243. β-Actin was used as protein loading control. n = 3.