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. Author manuscript; available in PMC: 2018 Feb 21.
Published in final edited form as: Phys Med Biol. 2016 Dec 20;62(4):1269–1290. doi: 10.1088/1361-6560/aa54c7

Figure 16. Intrinsic threshold histotripsy: Bubble cloud nucleation schematic.

Figure 16

Schematic shows proposed method of bubble cloud formation in intrinsic threshold histotripsy in which ultrasound beams constructively interfere as they propagate towards the focal region until the peak negative pressure reaches the intrinsic threshold. Once the intrinsic threshold is reached, a cavitation bubble is generated, and the pressure drops below the intrinsic threshold for a short distance. The beams then continue to propagate until intrinsic threshold is reached once again, with this process repeating through the entire focal volume.