Table 2.
Classification of atherosclerotic lesions in chow-fed ApoE−/− and ApoE−/−/P2Y2R−/− mice.
| Standard diet (n = 12) (n = 12) | ApoE−/− | ApoE−/−/P2Y2R−/− | |
|---|---|---|---|
| No lesion | – | 9 | No foam cell |
| Category 1 formation | – | 3 | Early foam cell |
| Category 2 | 12 | – | Regular fatty streaks |
| Category 3 | – | – | Mild plaque |
| Category 4 | – | – | Moderate plaque |
| Category 5 | – | – | Severe plaque |
Sinus aortic lesions were classified into the following categories as previously described [16]. (1) Early foam cell formation: up to 10 foam cell per section are present in the intima; (2) regular fatty streaks: >10 cells present in the intima; (3) mild plaque: extension of foam cells into the media: (4) moderate plaque: foam cells in the media, fibrosis, cholesterol clefts, mineralization and/or necrosis of the media; (5) severe plaque: similar to category 4 but more extensive and deeper into the media.