TABLE I.
Chromosome “Fragile Sites” Observed on Distal Xq in 14 of 161 Individuals Screened for the Fragile X Syndrome
| Patient | Age (yr) | Sex | Culture Medium/supplement | No. cells counted | Fragile site (No. observed) |
|---|---|---|---|---|---|
| A | 47 | M | M199/ | 100 | Xq26 (1) |
| RPMI 1640/FUdR | 50 | — | |||
| RPMI 1640/BrdU | 50 | — | |||
| B | 27 | M | M199/ | 50 | Xq26 (1) |
| RPMI 1640/FUdR | 25 | — | |||
| RPMI 1640/BrdU | 50 | — | |||
| C | 50 | M | M199/ | 50 | — |
| RPMI 1640/FUdR | 63 | Xq26 (1) | |||
| RPMI 1640/BrdU | 50 | — | |||
| D | 40 | M | M199/ | 50 | — |
| RPMI 1640/FUdR | 25 | Xq26 (1) | |||
| RPMI 1640/BrdU | 50 | — | |||
| E | 27 | F | M199/ | 68 | — |
| RPMI 1640/FUdR | 132 | Xq26 (1) TSCa (1) |
|||
| F | 44 | M | M199/ | 50 | — |
| RPMI 1640/FUdR | 25 | Xq26 (1) | |||
| RPMI 1640/BrdU | 50 | — | |||
| G | 46 | M | M199/ | 50 | — |
| RPMI 1640/FUdR | 25 | — | |||
| RPMI 1640/BrdU | 50 | Xq27.2 (1) | |||
| H | 76 | M | M199/ | 50 | — |
| RPMI 1640/FUdR | 94 | — | |||
| RPMI 1640/BrdU | 200 | Xq27.2 (1) | |||
| I | 42 | M | M199/ | 153 | TSCa (1) |
| RPMI 1640/FUdR | 79 | — | |||
| J | 41 | M | M199/ | 30 | — |
| RPMI 1640/FUdR | 122 | TSCa (1) | |||
| K | 28 | M | M199/ | 50 | Xq27.3 (13) |
| RPMI 1640/FUdR | 25 | Xq27.3 (12) | |||
| RPMI 1640/BrdU | 50 | — | |||
| L | 75 | M | M199/ | 85 | — |
| RPMI 1640/FUdR | 50 | Xq27.3 (9) | |||
| RPMI 1640/BrdU | 50 | — | |||
| M | 47 | M | M199/ | 50 | Xq27.3 (18) |
| RPMI 1640/FUdR | 25 | Xq27.3 (15) | |||
| RPMI 1640/BrdU | 50 | — | |||
| N | 37 | M | M199/ | 50 | Xq27.3 (23) |
| RPMI 1640/FUdR | 25 | Xq27.3 (9) | |||
| RPMI 1640/BrdU | 50 | — |
a
Nonspecific telomeric structural changes at Xq28.