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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: J Glaucoma. 2017 Jun;26(6):592–601. doi: 10.1097/IJG.0000000000000621

Table 6.

Diagnostic performance of peripapillary retinal volume for early primary open angle glaucoma, with best sensitivity and specificity values for 3 circular grids of different diameters.

Cutoff,
mm3 (≤)		 Sensitivity
(CI)		 Specificity
(CI)		 PLR
(CI)		 NLR
(CI)		 PPV
(CI)		 NPV
(CI)
OCA1
Superior 0.33 81.82
(64.5–93.0)		 65.67
(53.1–76.8)		 2.38
(1.9–3.0)		 0.28
(0.1–0.6)		 54.0
(39.3–68.2)		 88.0
(75.5–95.5)
Temporal 0.28 63.64
(45.1–79.6)		 77.61
(65.8–86.9)		 2.84
(2.1–3.8)		 0.47
(0.2–0.9)		 58.3
(40.8–74.5)		 81.2
(69.5–89.9)
Inferior 0.31 90.91
(75.7–98.1)		 85.07
(74.3–92.6)		 6.09
(5.3–7.1)		 0.11
(0.03–0.4)		 75.0
(58.8–87.3)		 95.0
(86.0–99.0)
Nasal 0.29 75.76
(57.7–88.9)		 58.21
(45.5–70.2)		 1.81
(1.4–2.4)		 0.42
(0.2–0.8)		 47.2
(33.2–61.5)		 83.0
(69.2–92.4)
OCA2
Superior 0.42 63.64
(45.1–79.6)		 86.57
(76.0–93.7)		 4.74
(3.6–6.2)		 0.42
(0.2–0.9)		 70.0
(50.6–85.3)		 82.9
(71.9–90.9)
Temporal 0.41 81.82
(64.5–93.0)		 58.21
(45.5–70.2)		 1.96
(1.5–2.5)		 0.31
(0.1–0.7)		 49.1
(35.2–63.1)		 86.7
(73.0–95.0)
Inferior 0.43 87.88
(71.8–96.6)		 82.09
(70.8–90.4)		 4.91
(4.1–5.8)		 0.15
(0.05–0.4)		 70.7
(54.5–83.9)		 93.2
(83.5–98.1)
Nasal 0.39 69.70
(51.3–84.4)		 62.69
(50.0–74.2)		 1.87
(1.4–2.5)		 0.48
(0.3–0.9)		 47.9
(33.3–62.8)		 80.8
(67.5–90.4)
OCA3
Superior 1.55 93.33
(77.9–99.2)		 59.09
(46.3–71.0)		 2.28
(1.8–2.8)		 0.11
(0.03–0.4)		 50.9
(37.1–64.6)		 95.1
(83.3–99.4)
Temporal 1.42 51.52
(33.5–69.2)		 76.12
(64.1–85.7)		 2.16
(1.5–3.1)		 0.64
(0.4–1.1)		 51.5
(33.5–69.2)		 76.1
(64.1–85.7)
Inferior 1.42 78.79
(61.1–91.0)		 83.58
(72.5–91.5)		 4.80
(3.9–5.9)		 0.25
(0.1–0.6)		 70.3
(53.0–84.1)		 88.9
(78.3–95.5)
Nasal 1.43 75.86
(56.5–89.7)		 70.00
(56.8–81.2)		 2.53
(1.9–3.3)		 0.34
(0.2–0.7)		 55.0
(38.5–70.7)		 85.7
(72.6–94.1)

CI: 95% confidence interval, PLR: positive likelihood ratio, NLR: negative likelihood ratio, PPV: positive predictive value, NPV: negative predictive value, OCA1: outer circumpapillary annulus of circular grid 1, OCA2: outer circumpapillary annulus of circular grid 2, OCA3: outer circumpapillary annulus of circular grid 3.