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Equivalent gene expression in intestinal organoid culture. (A) BMAL1+/+, BMAL1-/-, and BMAL1+/+ organoids treated with anti-TNF show similar expression of the JNK target gene CD44 (P = .8363). (B) BMAL1-/- organoids show similar expression of the cell cycle regulators CCNB1 (P = .5970), CCNE1 (P = .4307), C-MYC (P = .7082), and E2F (P = .8220) when stimulated with TNF.
