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Mesalamine does not increase the accumulation of Th1 cells and Th17 cells in the LP of the colon. Wild-type mice were orally treated with 50 mg/kg of mesalamine for 2 weeks. (A) Percentages of IFN-γ+ cells (n = 8 mice per group) or IL17+ cells (n = 4 mice per group) within the CD3+CD4+ cell population isolated from the colon LP. (B) T-bet and RorC mRNA levels in the colon (n = 4 mice per group). Error bars represent mean ± SEM. 5-ASA, mesalamine.
