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. 2017 Jun 1;7:2593. doi: 10.1038/s41598-017-02464-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Megakaryocyte differentiation, from left to right: Megakaryocyte progenitor cells (MPC) differentiate to erythrocytes (upper branch) or megakaryocytes (lower branch), while specific transcription factors for each branch drive the differentiation process (figure adapted from¹⁰). (B) Heatmaps on four in silico predicted transcription factor binding sites in the mm10 mouse genome assembly. Binding sites are located in the center, surrounded by the ATAC read signal from −1 kb to +1 kb. A globally normalized color scale represents the strength of the respective ATAC signal. The binding profile is shown at the top of each heatmap. Heatmaps from the left to the right represent Gabp-alpha, Fli1and Klf1 as Megakaryocyte progenitor specific transcription factors and Pax7 as Megakaryocyte unrelated factor.