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Protective activity of the glycoconjugates.
| Experimental series | Immunogen | Single dose (carbohydrate content) per mouse, μg | Survivors |
|
|---|---|---|---|---|
| D0 | D7 | |||
| 1 | Tetra-bovine serum albumin (BSA) | 2.5 | 8 | 8*** |
| 5.0 | 8 | 8*** | ||
| 10 | 8 | 7** | ||
| Hexa-BSA | 2.5 | 8 | 1 | |
| 5.0 | 8 | 2 | ||
| 10 | 8 | 7** | ||
| Octa-BSA | 2.5 | 8 | 3 | |
| 5.0 | 8 | 8*** | ||
| 10 | 8 | 6** | ||
| Control | Saline | 8 | 0 | |
| 2 | Tetra-BSA | 1.25 | 10 | 10*** |
| Octa-BSA | 1.25 | 10 | 7** | |
| CP-CRM197 | 1.1 | 4 | 4*** | |
| Control | Saline | 10 | 0 | |
| 3 | Hexa-BSA | 10 | 10 | 10*** |
| CP | 5.0 | 10 | 2 | |
| Control | Saline | 10 | 1 | |
**P < 0.01, *** P < 0.001.
