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. 2017 Jun 2;7:115. doi: 10.3389/fonc.2017.00115

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Copyright © 2017 Roy, Libard, Weishaupt, Gustavsson, Uhrbom, Hesselager, Swartling, Pontén, Alafuzoff and Tchougounova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mast cells (MCs) induce significant changes in expression levels of genes associated with brain metastasis cells. (A) Heatmap of the top 100 differentially expressed genes (DEGs) in NCI-H1915 cells after MC coculture. (B) Heatmap of the top 100 DEGs in U3333MET cells after MC coculture. (C) Venn diagram comparing the DEGs between NCI-H1915 cells and U3333MET cells (***p < 0.001).