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. 2017 Jun 2;11:158. doi: 10.3389/fncel.2017.00158

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Copyright © 2017 Noli, Sanna, Brancia, D’Amato, Manconi, Vincenzoni, Messana, Melis, Argiolas, Ferri and Cocco.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of acute, subchronic or chronic PCP (phencyclidine) treatment on prepulse inhibition (PPI) response. Rats were treated once a day as well as once a day for 8 or 21 days with PCP (2.5 mg/kg, SC) or saline (1 mL/kg, SC) and tested for the PPI of the acoustic startle response 30 min or 24 h after the last drug treatment. AC, acute treatment; SNW and SW, subchronic treatment without or with 24 h wash out, respectively; CNW and CW, chronic treatment without or with 24 h wash out, respectively. Mean values (SEM) from 8 rats/group. ***p < 0.001 vs. the corresponding saline treated rats; ^###p < 0.001 vs. acutely (1 day) treated rats; ^§§§p < 0.001 vs. the corresponding no washed out rats (two way ANOVA followed by Bonferroni’s post hoc comparisons).