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. 2017 Jun 2;11:158. doi: 10.3389/fncel.2017.00158

Figure 3.

Figure 3

Effect of PCP treatment on the content of VGF peptides in the prefrontal cortex and nucleus accumbens. In the prefrontal cortex, we found an increase in VGF C-terminus levels after sub-chronic and chronic PCP treatment, as well as in TLQP peptides exclusively after sub-chronic PCP treatment when compared to the respective saline treated rats (p < 0.01). Conversely, in the nucleus accumbens, PCP treatment produced a decrease in the VGF C-terminus levels after all types of treatments (acute, sub-chronic and chronic), while N-terminus- and CGGE-peptide levels were reduced after chronic PCP treatment when compared to the respective groups of saline-treated rats (p < 0.01). The levels of all VGF peptides changed in PCP- (sub-chronic and chronic) treated rats returned to similar levels to those of saline-treated controls after 1 day from the last PCP treatment (sub-chronic and chronic wash out groups). Mean values are (SEM) from eight rats/group. *p < 0.01 vs. the corresponding saline-treated rats (one way ANOVA followed by Bonferroni’s post hoc comparisons). Pmol/g: picomoles/grams.