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Mechanisms underlying the relationship between HT and kidney disease.
| In situ immune response against thyroglobulin (TG) deposition at subepithelial level |
| Circulating TG–anti-TG complexes trapped at subendothelial level due to increased glomerular permeability |
| Megalin (gp330) as a possible immunologic target |
| Epitope spreading |
| Genetic predisposition and cross-reactivity between antigens |
