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a, amino acid sequence of the human invariant chain protein. The MHCII-binding core sequence of CLIP1 is MRMATPLLM, and that of CLIP2 is PLLMQALPM. The MHCII-binding core sequence of CLIP3 is unknown. b, solution NMR structure of the truncated human invariant chain protein (residues 118–192; Protein Data Bank code 1IIE). The invariant chain protein is a homotrimer and associates with three class-II major histocompatibility complex proteins simultaneously in the endoplasmic reticulum.
