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Close-up views of the P4 pocket in DQ2.5·CLIP1 (Protein Data Bank code 5KSU) (a), DR1·CLIP1 (Protein Data Bank code 3PDO) (b), DR3·CLIP1 (Protein Data Bank code 1A6A) (c), and I-Ab·CLIP1 (Protein Data Bank code 1MUJ) (d). The protein surfaces of the MHCII α-chain and β-chain are colored blue and pink, respectively. β-Chain residues that line the P4 pocket are shown as a stick model (pink, carbon; red, oxygen). CLIP1 peptide is shown in yellow.
