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The regions of contact shared by MHCII and HLA-DM are indicated as corresponding ovals. The protein surface color represents Adaptive Poisson Boltzmann Solver-generated electrostatics surface of MHC class-II proteins at pH 5.5 (red, negative; blue, positive; white, neutral). a, DQ2.5 from DQ2.5·CLIP1 (Protein Data Bank code 5KSU); b, DR1 from DR1·HA·DM (Protein Data Bank code 4FQX); c, DM from DR1·HA·DM (Protein Data Bank code 4FQX).
