Figure 5.

Population variation in human IGFALS. Diagram of the human IGFALS precursor showing alternative 64 and 27 amino acid (AA) signal peptides (SP) (the former has not been determined experimentally) and the 578-amino acid mature protein. The cysteine-rich domains (CR1 and CR2) and the leucine-rich region are indicated in mature IGFALS. The overall population prevalence of variant alleles for each part of the molecule is listed below the map, and the location of the two most common variants is depicted in single-letter amino acid code. The scale bar represents 50 amino acids.