Table 2.

Human population variation in IGF and insulin receptors

Protein	Number of codonsa	Missense and in-frame insertions-deletions	Frame shifts; stop codons	Splicing site changes	Loss of start codon	Loss of stop codon	Total number of different changes	Variants per codon	Total variant alleles in population
IGF1R	1367	413	8	4	0	2	427	0.31	3.3%
INSR	1382	316	10	5	0	0	331	0.24	2.1%
IGF2R	2491	856	12	4	0	0	872	0.35	121.3%
CDMPR	277	82	5	4	2	0	93	0.34	13.4%

^a Based on transcripts used in ExAC database.