Table 3.

The G856R mutation hyperpolarizes activation and slows deactivation kinetics but does not alter fast inactivation in HEK293 cells

The G856D data were published by Hoeijmakers et al. (14).

Nav1.7	Current density		Activation			Deactivation		Steady-state fast inactivation			Slow inactivation
	pA/pF	n	V1/2,act	k	n	−40 mV	n	V1/2,fast	k	n	V1/2,slow	k	A%	n
			mV			ms		mV			mV
WT	366 ± 48	19	−17.2 ± 1.1	8.2 ± 0.3	17	0.22 ± 0.02	20	−80.1 ± 1.4	7.9 ± 0.2	23	−76.9 ± 1.6	12.1 ± 0.7	17.3 ± 0.9	12
G856R	557 ± 65a	22	−28.4 ± 1.3a	8.3 ± 0.3	18	1.09 ± 0.08a	15	−82.7 ± 1.1	8.1 ± 0.3	17	−86.1 ± 1.6a	7.6 ± 0.4a	3.9 ± 0.6a	11
WT	504 ± 61	25	−22.7 ± 0.8	6.3 ± 0.2	23	0.52 ± 0.05	13	−79.0 ± 1.0	7.0 ± 0.2	22	−62.9 ± 1.3	13.8 ± 0.7	8.7 ± 0.9	13
G856D	118 ± 13a	28	−32.0 ± 0.6a	9.3 ± 0.2a	27	3.06 ± 0.12a	19	−72.8 ± 0.8a	6.5 ± 0.1 a	27	−78.0 ± 1.1a	6.5 ± 0.2 a	10.5 ± 1.0	16

^a p < 0.05 versus WT channels.