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Oxygen sensitivity of the metabolic response to NO. A, astrocytes expressing the glucose sensor were first transiently depleted of glucose for calibration purposes and then exposed to increasing NO concentrations in the presence of 467 μm (high O2) and 62 μm (low O2; n = 10 cells from a single experiment). B, magnitude of the glucose depletion in three similar experiments, with 3–5 cells each. Line plot shows the average glucose depletion at each NO concentration.
