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. Author manuscript; available in PMC: 2018 May 17.
Published in final edited form as: ACS Chem Neurosci. 2017 Feb 13;8(5):1065–1073. doi: 10.1021/acschemneuro.6b00413

Figure 3. Lorcaserin suppresses cue reactivity in the extinction-reinstatement model.

Figure 3

[A] Total presses (mean ± SEM) on the active (black circles) or inactive lever (white circles; left X-axis), and total number of oxycodone infusions obtained (gray circles; right X-axis) are presented for the acquisition of oxycodone self-administration. [B] The effects of lorcaserin (0.25, 0.5, 1 mg/kg) on previously active and inactive lever presses (mean ± SEM) following extinction training are presented. The “extinction baseline” was calculated as the mean total lever presses of all rats on the active (9.2 ± 2.9) or inactive lever (5.8 ± 1.1) during the last 60-min extinction session. Lorcaserin (0.5 and 1 mg/kg) significantly reduced previously active lever presses relative to vehicle (*p < 0.05 vs. VEH).