Table 3.
FAIME pathway signature
| KEGG | Increased cluster expression | FDR | Pathways |
|---|---|---|---|
| hsa00860 | 1 | 1.62242E-14 | Porphyrin and chlorophyll metabolism |
| hsa04080 | 1 | 3.81206E-12 | Neuroactive ligand-receptor interaction |
| hsa00982 | 1 | 5.25302E-12 | Drug metabolism: cytochrome P450 |
| hsa00980 | 1 | 2.24239E-11 | Cytochrome P450 Metabolism of xenobiotics |
| hsa04610 | 1 | 2.73693E-10 | Complement and coagulation cascades |
| hsa04974 | 1 | 2.75036E-10 | Protein digestion and absorption |
| hsa00830 | 1 | 9.10577E-10 | Retinol metabolism |
| hsa04740 | 1 | 3.45204E-09 | Olfactory transduction |
| hsa00983 | 1 | 1.01799E-08 | Drug metabolism: other enzymes |
| hsa00500 | 1 | 1.1871E-08 | Starch and sucrose metabolism |
| hsa05144 | 1 | 1.23834E-08 | Malaria |
| hsa04140 | 1 | 3.1348E-07 | Regulation of autophagy |
| hsa04976 | 1 | 1.03166E-06 | Bile secretion |
| hsa00040 | 1 | 2.3345E-06 | Pentose and glucuronate interconversions |
| hsa04145 | 1 | 2.81301E-06 | Phagosome |
| hsa05210 | 2 | 1.51002E-12 | Colorectal cancer |
| hsa04710 | 2 | 3.91953E-11 | Circadian rhythm: mammal |
| hsa04660 | 2 | 2.75036E-10 | T-cell receptor signaling pathway |
| hsa00970 | 2 | 1.82174E-08 | Aminoacyl-tRNA biosynthesis |
| hsa05340 | 2 | 1.82174E-08 | Primary immunodeficiency |
| hsa04070 | 2 | 2.32538E-08 | Phosphatidylinositol signaling system |
| hsa00670 | 2 | 3.3263E-08 | One carbon pool by folate |
| hsa03018 | 2 | 1.89728E-07 | RNA degradation |
| hsa00061 | 2 | 2.35402E-07 | Fatty acid biosynthesis |
| hsa03015 | 2 | 3.44253E-07 | mRNA surveillance pathway |
| hsa00780 | 2 | 9.72831E-07 | Biotin metabolism |
| hsa04370 | 2 | 1.69033E-06 | VEGF signaling pathway |
| hsa00532 | 2 | 2.68975E-06 | Glycosaminoglycan biosynthesis chondroitin |
| hsa00785 | 2 | 3.19258E-06 | Lipoic acid metabolism |
| hsa05110 | 2 | 7.04905E-06 | Vibrio cholerae infection |
KEGG, Kyoto Encyclopedia of Genes and Genomes; mRNA, messenger RNA; tRNA, transfer RNA.