Figure 2.

A kinetic diagram used for the development of full and simplified mathematical models. Seven possible kinetic states for tau protein and kinetic processes between these states are displayed. These are the states for which the conservation equations (equations (2.1)–(2.7)) are written. Four of these kinetic states are identical to the kinetic states in a slow axonal transport model for NFs (see fig. 4 of Jung & Brown [29] and fig. 1 of Li et al. [30]). Kinetic processes that are neglected in the simplified model are shown by dashed lines. Kinetic states where tau has mobility are also indicated.