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. 2017 May 16;4(6):403–410. doi: 10.1002/acn3.420

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© 2017 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Correlation between GMFC‐MLD score and demyelination load. (A) The positive correlation between the corrected demyelination load and gross motor function loss, indicated by higher GMFC‐MLD scores (ρ = 0.55, P < 0.0001). (B) The spatial association between demyelination of white matter (WM) in the central region and gross motor deterioration (higher GMFC‐MLD scores). For illustration, significance thresholds of 5% false discovery rate correction24, 34 are displayed. The color bar represents z scores.