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. 2017 May 4;4(6):392–402. doi: 10.1002/acn3.416

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© 2017 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Diagnostic accuracy of biomarkers predicts brain death. Area under the receiver‐operating characteristic curve (AUC) for CSF glutamate (A) and lactate (B) concentrations. ROC curves based on glutamate and lactate were used as a predictor of death in TBI patients. The cutoff for glutamate was set at >57.75, providing 80% of sensitivity and 84.62% of specificity (AUC: 0.8214, 95% CI, CL: 54.55–98.08%). The cutoff for lactate was set at >4.650, providing 100% of sensitivity and 85.71% of specificity (AUC: 0.8810, 95% CI, CL: 54.55–98.08%). Both biomarkers presented high specificity and sensitivity for discriminating TBI survival and nonsurvival patients.