Figure 6.

Schematic model of the interplay of autophagy receptors with MeV replication. NDP52, OPTN, and T6BP could all play a dual function in autophagy: to target selective substrates towards autophagosomes and to regulate substrate-containing autophagosome maturation (which could be those for which they targeted selective substrates), for an efficient degradation. Only autophagosome maturated via an NDP52 or T6BP pathway are exploited by MeV to improve its replication. Such exploitation could occur via the usage of each receptor for their functions in the targeting and/or the maturation processes (dashed arrows).