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. 2017 May 12;49(5):e329. doi: 10.1038/emm.2017.41

Figure 1.

Figure 1

TMEM119 overexpression is associated with poor survival of osteosarcoma patients. (a) TMEM119 mRNA expression was significantly higher in osteosarcoma tissues (n=81) than in normal osteoblasts (n=6) from GSE42352 (P<0.05). (b) The level of TMEM119 mRNA was significantly elevated in osteosarcoma tissues (n=45) compared to that in bone cyst tissues (n=20) from patients admitted to Affiliated Yixing Hospital of Jiangsu University and the First Affiliated Hospital of Soochow University (P<0.0001). (c) TMEM119 protein expression was determined by western blotting analysis in osteosarcoma (T1–T4) and bone cyst tissues (N1–N4). The experiments were repeated at least three times with similar results. (d) TMEM119 protein expression in osteosarcoma tissues was determined by IHC staining. Magnification: × 200, scale bars: 100 μm. (e) The overall survival time of 100 patients with osteosarcoma based on IHC staining (P=0.0003, HR=0.411, 95% CI: 0.254–0.668). (f) Survival analysis of patients from GSE39055 (P=0.0011, HR=0.118, 95% CI: 0.0.28–0.428).